Housed at the University of California C Center in Fresno, the Armenian Museum of Fresno, (a.k.a Armenian Heritage Museum, California Public Benefit Corporation), was established in 2003 as a 501 (c) 3 non-profit organization. The Museum highlights the contributions of Armenians and Armenian-Americans to California and the Central Valley in particular, complementing the cultural fabric of Central California. It will promote and showcase rotating exhibitions of the fine and performing arts.

To that end, since its inception the Museum has undertaken several activities that include hosting the National Chamber Orchestra of Armenia under the direction of Maestro Aram Garabegian in 2002, 2005 and 2008, the Isabel Bayrakdarian solo concert accompanied with pianist Serouj Kerajian in 2005, the Arshile Gorky Festival and Exhibition in 2006, and the year-long 2008 William Saroyan Centennial celebration. The museum also organized and sponsored Duo-Piano recitals in Fresno and Los Angeles in 2010 and 2011. Previous art exhibitions include artists Rafayel Atoyan, Boghos Boghossian, Hovik Khochinian,Varaz Samuelian, Henrik Vardeniktsy and Nishan DerKalousdian.

The Armenian Museum, in cooperation with the Fresno Philharmonic and the Armenian Genocide Centennial Committee of Fresno, presented "Witness and Rebirth: An Armenian Journey", a concert commemorating the Centennial of the Armenian Genocide, which included the world premiere of Serouj Kradjian's "Cantata for Living Martyrs". Currently, photos of Armenia by Jane Kardishian, MD and a collection of paintings by contemporary Armenian artists from the Arame Gallery, US Branch, are exhibited at the Armenian Museum. In May 2015, the Museum published a new translation of Bedros Donabedian's The Cry of the Tormented, a collection of hundreds of letters sent by Armenian going through the Genocide. These activities are supported by the financial contributions from corporations and the general public.